Protein losing enteropathy (PLE) in dogs

What is protein losing enteropathy in dogs?

Protein-losing enteropathy (PLE) refers to an excessive loss of protein from the bloodstream in the intestinal tract. The word “enteropathy” means any disease of the intestinal system. Protein losing enteropathy is not a specific disease but rather a syndrome associated with several gastrointestinal (GI) diseases in dogs that result in a loss of protein from the intestines.

Normally, small amounts of protein leak out of the blood vessels as they pass through the intestines; these leaked plasma proteins are broken down and then reabsorbed by the body and used to make more proteins. With PLE, the mucosal layer that lines the inner surface of the intestine is compromised, allowing more protein-rich fluid to leak out than the body can replace. PLE can lead to a state of hypoproteinemia, a condition where there is an abnormally low level of protein in the blood.

There are a number of diseases that can damage the intestines sufficiently to cause this extra protein loss. Primary gastrointestinal disease, heart disease and diseases of the lymphatic system can all cause PLE.

PLE in dogs can affect any breed or age, but some breeds show a predisposition for certain disorders linked to PLE. These breeds include the Soft-coated Wheaten Terrier, Basenji, Yorkshire Terrier, Shar Peis and Norwegian Lundehund. However, no genetic predisposition has yet been proven.

Protein losing enteropathy (PLE) in dogs



Symptoms of protein losing enteropathy in dogs

While symptoms of PLE in dogs may initially be subtle, if left untreated they can quickly progress to become severe and potentially life threatening.  Weight loss, diarrhoea and vomiting are the most common clinical signs, but are not present in every case.

Observable symptoms of PLE in dogs include:

  • Bouts of diarrhoea
  • Chronic diarrhoea
  • Blood-tinged, mucoid, dark, sticky faeces (melaena)
  • Weight loss
  • Lack of energy (lethargy)
  • Difficulty breathing (dyspnoea) (due to fluid accumulation in the chest cavity)
  • Enlarged abdomen, pot-bellied appearance (due to fluid accumulation within the abdomen)
  • Legs and feet may be puffy or swollen (oedema)
  • Decreased appetite (anorexia)
  • Being a “picky” eater
  • Vomiting

dog vomiting full


Your veterinarian may detect additional symptoms on physical examination:

  • Muscle wasting
  • Malnutrition
  • Thickened loops of intestine on palpation
  • Fluid in the abdomen
  • Abnormal rectal exam
  • Increased lymph nodes
  • A heart murmur
  • Dull lung sounds (from fluid on the lungs)

Maltese with enlarged abdomen due to PLE. protein losing enteropathy in dogs ple in dogs protein loss in dogs canine protein losing enteropathy ple dogs prognosis

Maltese with enlarged abdomen due to PLE.
Source: https://babytoboomer.com/wp-content/uploads/2016/11/Maltese-PLE.jpg



Causes of protein losing enteropathy in dogs

Excessive loss of protein can occur through the gastrointestinal (GI) tract as a result of many conditions but is most commonly caused in dogs by inflammatory bowel disease (inflammation of the intestines) and lymphoma (cancer of the lymphoid tissues in the GI tract).

Diseases and conditions of the GI tract that can lead to PLE include:

  • Inflammatory bowel disease (IBD), including lymphocytic-plasmacytic enteritis, eosinophilic enteritis, granulomatous enteritis and histiocytic-ulcerative colitis
  • Lymphatic diseases like intestinal lymphangiectasia (pathologic dilation of lymph vessels), lymphoma
  • Viral gastroenteritis – for example, parvovirus
  • Bacterial gastroenteritis – for example, salmonella
  • Fungal gastroenteritis – for example, histoplasmosis
  • Parasitic enteritis – for example, Giardia duodenalis, hookworms and whipworms (a common cause in juvenile animals)
  • Adverse food reactions – for example, food intolerance
  • Mechanical GI disease – for example, chronic foreign body irritation (without creating a blockage)
  • Intestinal cancer – for example, carcinoma, neoplasia
  • Gastrointestinal ulceration (ulcers in the stomach or intestines)
  • Gastrointestinal haemorrhage (this may occur with hypoadrenocorticism or GI ulceration)
  • Chronic intussusception (a common cause in juvenile animals)


There are a number of cardiovascular diseases and conditions that can cause of PLE in dogs, including:

  • Infiltrative disease
  • Venous congestion
  • Portal hypertension
  • Posterior caval syndrome
  • Congestive heart failure


Some of the rarer causes of PLE in dogs include:

  • Small intestinal bacterial overgrowth (SIBO)
  • Hypoalbuminaemia causing intestinal mural oedema
  • Increased activation of tissue plasminogen activator
  • Systemic lupus erythematosis (SLE)
  • Chemotherapy or radiotherapy


How is protein losing enteropathy in dogs diagnosed?

If you notice any of the symptoms listed above, consult your veterinarian immediately. Your vet will perform a physical examination and will ask you for a thorough history of your dog’s health and onset of symptoms you have observed.

In most cases, a combination of the clinical signs, laboratory tests and imaging findings with the analysis of endoscopic intestinal biopsies can lead to at least a provisional diagnosis of PLE and guide initial treatment. However, sometimes a final diagnosis is only made after assessing the patient’s response to treatment.

As it is a syndrome rather than a disease, once PLE has been confirmed it is essential to find the underlying cause. Often this can only be accomplished by ruling out other possible causes. Although any intestinal disease that is severe enough to cause a net loss of protein can result in PLE, some diseases are commonly recognised to cause PLE, such as:

  • Intestinal lymphangiectasia, characterised by dilation of the intestinal lymph vessels, believed to be the most common cause of PLE in dogs, can occur as a primary (congenital) or secondary (acquired) disease.
  • Inflammatory bowel disease (IBD), defined as chronic inflammation of the bowel wall (e.g., lymphoplasmacytic enteritis), must be severe in order to result in intestinal protein loss.
  • Lymphoma of the intestinal tract can cause hypoalbuminemia, abnormally low levels of albumin, a major blood protein, in 75% of dogs.
  • Adenocarcinoma and other tumours in the intestine may cause PLE due to blood loss and mucosal ulceration.
  • Gastroenteritis (from viral, fungal, or bacterial infections)
  • Stomach ulcers
  • Severe chronic starvation
  • Granulomatous infiltration of the intestines (secondary to fungal infections)
  • Abnormalities of the intestines (from a chronic foreign body, intestinal parasites, an intussusception, haemorrhagic gastroenteritis, etc.)
  • Ulcerative gastroenteritis
  • Hepatic (liver) and renal (kidney) disease


Tests that are typically performed to diagnose PLE and/or rule out other diseases include:

Laboratory tests

Standard laboratory testing will be performed, and a preliminary diagnosis of PLE can be made based on low albumin and protein levels in the blood work. Your vet may also check the blood vitamin levels, which will be low if your dog is losing protein from its intestines. Tests likely to be performed are:

  • Complete blood count (CBC) to examine the white and red blood cells and platelets
  • Biochemical profile to examine blood proteins, including albumin and globulin concentrations (which are typically decreased with PLE)
  • Electrolytes to examine the calcium, phosphorous and salt balance
  • Urinalysis to investigate the loss of protein from the kidneys (protein-losing nephropathy) as a possible cause
  • Faecal (stool) examination to check for intestinal parasites, intestinal infections and other indicators that your dog is losing protein from its intestines


Diagnostic imaging

Radiography (X-rays) will allow your vet to visually examine your dog’s chest and abdomen for internal ulcerations, abnormal accumulation of fluid or tumours. X-rays can be used to rule out evidence of heart disease, fungal infections, cancer or abnormal fluid accumulation in the organs or tissues.

Ultrasonography of the abdomen may be performed to measure the size of the intestines and look for evidence of increased lymph nodes, foreign bodies or cancer. Abdominal ultrasound can reveal changes to intestinal wall structure, including:

  • Thickening without loss of normal layers (indicative of inflammatory bowel disease)
  • Thickening with loss of layers (indicative of infiltrative intestinal neoplasia)
  • ‘Tiger stripes’, a possible indicator of lymphangiectasia

Abdominal ultrasound may also reveal an abnormal accumulation of fluid in the abdomen (ascites) or lungs (pleural effusion) and mesenteric lymphadenopathy, an inflammation of lymph nodes.



A small camera, attached to a tube, is passed through the dog’s mouth and/or anus into the intestines so that the walls of the stomach and intestinal tract can be visually examined for ulcers, tissue masses (tumours) or abnormalities in the wall or cell structure.

During the endoscopic procedure, tissue samples can be taken from the stomach, intestines and rectum for biopsy. Analysis of biopsied tissue is very useful for determining why an animal is losing protein through its intestines and can provide a definitive diagnosis of lymphoma and secondary lymphangiectasia.


Surgical exploration

Open abdominal surgery or “keyhole” surgery of the abdomen (laparoscopy) may be performed to evaluate all the organs and collect multiple, full-thickness biopsies, which may be necessary to rule out certain types of disease like lymphangiectasia.



Even with aggressive treatment, PLE can dramatically shorten the life expectancy of your dog, and untreated, it can be fatal. The sooner PLE is diagnosed, the better the long-term outcome. The condition varies in severity from mild to severe and prognosis depends on the underlying cause of PLE in each case. However, the long-term prognosis in most dogs is guarded.

As certain breeds show a predisposition to PLE or related diseases, including Yorkshire TerriersSoft-coated Wheaten TerriersBasenjis and Norwegian Lunehunds, dogs of these breeds showing any of the symptoms of PLE should immediately be examined. Soft-coated Wheaten terriers are known to have a median survival time of five months after diagnosis of PLE and of two months if they suffer from concurrent protein-losing nephropathy.

Prognosis may be worsened by the development of life-threatening complications such as pulmonary thromboembolism (a blockage in the arteries that supply blood to the lungs caused by blood clots) and decreased serum albumin concentration (hypoalbuminemia).



Treatment for protein losing enteropathy in dogs

As there are many underlying causes of PLE in dogs, there is no single treatment protocol for this syndrome and every patient has different needs. The therapeutic aims are to treat the underlying cause and to support the patient.  In most cases, treatment will be determined by the underlying disease. Your vet will develop a treatment plan to help you manage your dog’s symptoms, which will include exercise and a special diet to facilitate the absorption of nutrients by your dog’s body.

Depending on the underlying causes of PLE identified by the diagnostic tests, treatment may include:

  • Dietary changes such as a high protein diet for IBD or an ultra-low fat, easily digestible diet for intestinal lymphangiectasia (a dietary trial may be recommended for IBD)
  • Anti-inflammatory medication is the main treatment for IBD but can have unwanted side effects when used at higher doses
  • Procedures to remove the fluid from the chest or abdomen (e.g., thoracocentesis or abdominocentesis)
  • Plasma transfusions to increase plasma volume
  • Intravenous fluids to keep fluid within the blood vessels and help reduce fluid accumulation
  • Diuretics to reduce ascites or pleural effusion
  • Antithrombotic therapy such as low dose aspirin to reduce the risk of thrombosis
  • Dietary supplementation with calcium if a low serum concentration of ionised calcium is detected
  • Anti-emetics to treat nausea
  • Tube feeding, in cases of sever vomiting or unwillingness to eat
  • Synthetic colloids to restore plasma volume
  • Vitamin B12 (cobalamin) injections in cases of low blood concentrations (common in PLE patients)
  • Deworming (for parasitic infections)
  • Antiulcer medication (if gastric ulcers are present)
  • Surgery


Management and long-term care of PLE in dogs:

PLE sufferers are fragile because of their hypoalbuminemia, gastrointestinal disease and their potential to develop spontaneous blood clots. Supportive care is therefore extremely important and providing adequate nutrition is vital.

Regular follow-up examinations and testing will be required, including complete blood counts and biochemical profiles to check that your dog’s blood protein level is stable and not becoming dangerously low. Your vet will also check your dog for symptoms such as breathing difficulties fluid built up in the abdomen.


In a nutshell

Any intestinal disease, if severe enough, can result in protein losing enteropathy (PLE) in dogs. The underlying cause of PLE is disruption of the intestinal lining, leading to the abnormal loss of protein from the intestines. Because a number of diseases can lead to this condition, PLE is classified as being a syndrome rather than a disease.

As there are a diverse range of underlying conditions that cause PLE, it may develop in dogs of any age, breed, or sex. However, some breeds have been demonstrated to be particularly at risk; these include Yorkshire Terriers, Soft Coated Wheaten Terriers, Norwegian Lundehunds, and Basenjis.

Many dogs with PLE have non-specific signs of gastrointestinal disease, however, the most common clinical signs are diarrhoea, vomiting, and weight loss. Diagnosis entails blood testing and other investigative tests to determine the underlying disease that may have caused the PLE. In general, treatment of PLE is determined by the underlying disease and the severity of the clinical signs. Modified nutrition is generally a part of the ongoing management of PLE. In some cases, the primary, underlying disease may not be treatable but even where aggressive treatment is undertaken, the long-term prognosis in most dogs with PLE is guarded.


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